Human herpesvirus 6A
| Human herpesvirus 6A | |
|---|---|
| Virus classification Edit this classification | |
| (unranked): | Virus |
| Realm: | Duplodnaviria |
| Kingdom: | Heunggongvirae |
| Phylum: | Peploviricota |
| Class: | Herviviricetes |
| Order: | Herpesvirales |
| Family: | Orthoherpesviridae |
| Genus: | Roseolovirus |
| Species: | Roseolovirus humanbeta6a
|
| Synonyms | |
| |
Human herpesvirus 6A (HHV-6A) is a species of virus in the genus Roseolovirus, subfamily Betaherpesvirinae, family Herpesviridae, and order Herpesvirales.[1][2]
HHV-6A and infertility
[edit | edit source]- A 2016 study showed that 43% of women with unexplained infertility tested positive for HHV-6A while 0% of women in the fertile control group tested positive. HHV-6A was found present in endrometrial epithelial cells from women with unexplained infertility. [3]
- A 2018 study reports the prevalence of HHV-6A in endometrial biopsies among women experiencing recurrent implantation failure after IVF/ET compared to control groups.[4]
- A 2019 study confirmed the presence of HHV-6A infection in 40% of idiopathic infertile women. Identifying the effect of HHV-6A infection on endometrial immune status opens up a new perspectives on fertility care. It's possible to choose antiviral therapies and non-hormonal approaches for women with unexplained infertility characterized by HHV-6A to increase their pregnancy rate.[5]
Taxonomy
[edit | edit source]In 1992 the two variants were recognised within Human herpesvirus 6 on the basis of differing restriction endonuclease cleavages, monoclonal antibody reactions,[6] and growth patterns.[7] In 2012 these two variants were officially recognised as distinct species by the International Committee on Taxonomy of Viruses.[8] Despite now being recognised as paraphyletic, the name Human herpesvirus 6 still sees usage in clinical contexts.
Pathology
[edit | edit source]Human herpesvirus 6A affects humans and includes several adult-derived strains. Its disease spectrum is not well defined, although it is thought by some to be more neurovirulent than Human herpesvirus 6B.[9][10]
References
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