HPTP

HPTP
	File:HPTP.svg
Clinical data
Drug class	Serotonergic and dopaminergic neurotoxin
Identifiers
	IUPAC name 4-[4-(4-chlorophenyl)-3,6-dihydro-2H-pyridin-1-yl]-1-(4-fluorophenyl)butan-1-one;
CAS Number	52669-92-8;
PubChem CID	171187;
ChemSpider	149659;
ChEBI	CHEBI:177523;
ChEMBL	ChEMBL3544895;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C21H21ClFNO
Molar mass	357.85 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN(CC=C1C2=CC=C(C=C2)Cl)CCCC(=O)C3=CC=C(C=C3)F;
	InChI InChI=1S/C21H21ClFNO/c22-19-7-3-16(4-8-19)17-11-14-24(15-12-17)13-1-2-21(25)18-5-9-20(23)10-6-18/h3-11H,1-2,12-15H2; Key:ZNOLNAPJKOYTHY-UHFFFAOYSA-N;

HPTP is a monoaminergic neurotoxin related to MPTP.^[1]^[2]^[3]^[4] It is the dehydration product of haloperidol.^[1]^[2]^[4] The agent is specifically a dopaminergic and serotonergic neurotoxin.^[1] HPTP is a prodrug of HPP⁺, which mediates its monoaminergic neurotoxicity.^[1]^[2]^[4] This is analogous to how MPP⁺ mediates the neurotoxicity of MPTP.^[1]^[2]^[4] Other related compounds include RHPTP and RHPP⁺.^[5]

References

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v t e Monoaminergic neurotoxins
Dopaminergic	2′-CH₃-MPTP (2′-methyl-MPTP) 2,4,5-THA 2,4,5-THMA 4-MMA 5-S-Cysteinyldopamine 5,6-DHT 6-Hydroxydopa 6-OHDA quinone 6,7-DHT ALDH inhibitors (e.g., disulfiram, methylmercury) Amphetamine Benomyl Daidzin Dieldrin DOPA quinone DOPAL DOPAL quinone Dopamine Dopamine quinone Fenpropathrin Haloperidol HPP⁺ HPTP Mancozeb Maneb Mephedrone Methamphetamine Methcathinone Methylone MPP⁺ (cyperquat) MPTP N-Methylnorsalsolinol Norsalsolinol Oxidopamine (6-OHDA) Paraquat Rotenone Salsolinol Ziram
Noradrenergic	2′-NH₂-MPTP (2′-amino-MPTP) 2,4,5-THA 4,5-DHT 5,6-DHT 5,7-DHT 6-Hydroxydopa DOPEGAL DSP-4 MDA (tenamfetamine) Oxidopamine (6-OHDA) Xylamine
Serotonergic	2′-NH₂-MPTP (2′-amino-MPTP) 2,4-DCA 2,4,5-THA 2,4,5-THMA 3-CA 3,4-DCA 4-CAB (α-ethyl-PCA) 4-CMA 4-HO-5-MeO-T 4,5-DHT 5-IAI 5-MAPB 5-MeO-DiPT 5,6-DHT 5,7-DHT 6,7-DHT αET ETAI Fenfluramine Haloperidol HHA (α-methyldopamine) HHMA (α-methylepinine, α,N-dimethyldopamine) HPP⁺ HPTP MBDB MDA (tenamfetamine) MDMA (midomafetamine) Mephedrone Methamphetamine Methylone Norfenfluramine PBA PBMA PCA PCMA PIA TAI
Unsorted	5-HIAL RHPP⁺ RHPTP
See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine metabolism modulators