HIST2H3C
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Histone H3.2 is a protein that in humans is encoded by the HIST2H3C gene.[1][2][3]
Function
[edit | edit source]Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy.[3]
Interactions
[edit | edit source]HIST2H3C has been shown to interact with NCOA6.[4]
References
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Further reading
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External links
[edit | edit source]- Overview of all the structural information available in the PDB for UniProt: Q71DI3 (Histone H3.2) at the PDBe-KB.
