HEPACAM2
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HEPACAM family member 2 is a protein that in humans is encoded by the HEPACAM2 gene. [1]
Function
[edit | edit source]This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology, and apoptosis.
Poly (ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients.
References
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Further reading
[edit | edit source]This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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