HDAC8
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Histone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene.[1][2][3]
Function
[edit | edit source]Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation / deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.[3]
Histone deacetylase 8 is involved in skull morphogenesis[4] and metabolic control of the ERR-alpha / PGC1-alpha transcriptional complex.[5]
Clinical significance
[edit | edit source]HDAC8 has been linked to number of disease states notably to acute myeloid leukemia and is related to actin cytoskeleton in smooth muscle cells. siRNA targeting HDAC8 showed anticancer effects.[6] Inhibition of HDAC8 induced apoptosis has been observed in T cell lymphomas.[7] In addition the HDAC8 enzyme has been implicated in the pathogenesis of neuroblastoma.[8] Therefore, there has been interest in developing HDAC8 selective inhibitors.[9][10] At least 20 disease-causing mutations in this gene have been discovered.[11]
Interactions
[edit | edit source]See also
[edit | edit source]References
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Further reading
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External links
[edit | edit source]- HDAC8+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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