H2AFY
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Core histone macro-H2A.1 is a protein that in humans is encoded by the H2AFY gene.[1][2][3]
Function
[edit | edit source]Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.[3] Expression of these isoforms is associated to several cancers, such as hepatocellular carcinoma.[4]
References
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Further reading
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External links
[edit | edit source]- PDBe-KB provides an overview of all the structure information available in the PDB for Human Core histone macro-H2A.1
