Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Glutathione S-transferase P is an enzyme that in humans is encoded by the GSTP1 gene .[ 1] [ 2]
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione . Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into four main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer , and other diseases.[ 3]
GSTP1 has been shown to interact with Fanconi anemia, complementation group C [ 4] [ 5] MAPK8 .[ 6]
GST-Pi is expressed in many human tissues, particularly in the biliary tree , renal distal convoluted tubules and lungs.[ 7]
Triple-negative breast cancer cells rely on glutathione-S-transferase Pi1, and inhibitors are being studied.[ 8] Piperlongumine has been found to silence the gene.[ 9]
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PDB gallery
10gs : HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH TER117
11gs : GLUTATHIONE S-TRANSFERASE COMPLEXED WITH ETHACRYNIC ACID-GLUTATHIONE CONJUGATE (FORM II)
12gs : GLUTATHIONE S-TRANSFERASE COMPLEXED WITH S-NONYL-GLUTATHIONE
13gs : GLUTATHIONE S-TRANSFERASE COMPLEXED WITH SULFASALAZINE
14gs : GLUTATHIONE S-TRANSFERASE P1-1 APO FORM 1
16gs : GLUTATHIONE S-TRANSFERASE P1-1 APO FORM 3
17gs : GLUTATHIONE S-TRANSFERASE P1-1
18gs : GLUTATHIONE S-TRANSFERASE P1-1 COMPLEXED WITH 1-(S-GLUTATHIONYL)-2,4-DINITROBENZENE
19gs : GLUTATHIONE S-TRANSFERASE P1-1
1aqv : GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH P-BROMOBENZYLGLUTATHIONE
1aqw : GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH GLUTATHIONE
1aqx : GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH MEISENHEIMER COMPLEX
1eog : CRYSTAL STRUCTURE OF PI CLASS GLUTATHIONE TRANSFERASE
1eoh : GLUTATHIONE TRANSFERASE P1-1
1gss : THREE-DIMENSIONAL STRUCTURE OF CLASS PI GLUTATHIONE S-TRANSFERASE FROM HUMAN PLACENTA IN COMPLEX WITH S-HEXYLGLUTATHIONE AT 2.8 ANGSTROMS RESOLUTION
1kbn : Glutathione transferase mutant
1lbk : Crystal structure of a recombinant glutathione transferase, created by replacing the last seven residues of each subunit of the human class pi isoenzyme with the additional C-terminal helix of human class alpha isoenzyme
1md3 : A folding mutant of human class pi glutathione transferase, created by mutating glycine 146 of the wild-type protein to alanine
1md4 : A folding mutant of human class pi glutathione transferase, created by mutating glycine 146 of the wild-type protein to valine
1pgt : CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE S-TRANSFERASE P1-1[V104] COMPLEXED WITH S-HEXYLGLUTATHIONE
1px6 : A folding mutant of human class pi glutathione transferase, created by mutating aspartate 153 of the wild-type protein to asparagine
1px7 : A folding mutant of human class pi glutathione transferase, created by mutating aspartate 153 of the wild-type protein to glutamate
1zgn : Crystal Structure of the Glutathione Transferase Pi in Complex with Dinitrosyl-diglutathionyl Iron Complex
20gs : GLUTATHIONE S-TRANSFERASE P1-1 COMPLEXED WITH CIBACRON BLUE
21gs :
22gs : HUMAN GLUTATHIONE S-TRANSFERASE P1-1 Y49F MUTANT
2a2r : Crystal Structure of Glutathione Transferase Pi in complex with S-nitrosoglutathione
2a2s : Crystal Structure of Human Glutathione Transferase in complex with S-nitrosoglutathione in the absence of reducing agent
2gss : HUMAN GLUTATHIONE S-TRANSFERASE P1-1 IN COMPLEX WITH ETHACRYNIC ACID
2j9h : CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE-S-TRANSFERASE P1-1 CYS-FREE MUTANT IN COMPLEX WITH S-HEXYLGLUTATHIONE AT 2.4 A RESOLUTION
2pgt : CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE S-TRANSFERASE P1-1[V104] COMPLEXED WITH (9R,10R)-9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHRENE
3gss : HUMAN GLUTATHIONE S-TRANSFERASE P1-1 IN COMPLEX WITH ETHACRYNIC ACID-GLUTATHIONE CONJUGATE
3pgt : CRYSTAL STRUCTURE OF HGSTP1-1[I104] COMPLEXED WITH THE GSH CONJUGATE OF (+)-ANTI-BPDE
4gss : HUMAN GLUTATHIONE S-TRANSFERASE P1-1 Y108F MUTANT
4pgt : CRYSTAL STRUCTURE OF HGSTP1-1[V104] COMPLEXED WITH THE GSH CONJUGATE OF (+)-ANTI-BPDE
5gss : HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH GLUTATHIONE
6gss : HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH GLUTATHIONE
7gss : HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH GLUTATHIONE
8gss : HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH GLUTATHIONE
9gss : HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH S-HEXYL GLUTATHIONE
![1pgt: CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE S-TRANSFERASE P1-1[V104] COMPLEXED WITH S-HEXYLGLUTATHIONE](/index.php/File:PDB_1pgt_EBI.jpg){kind=link}
![2pgt: CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE S-TRANSFERASE P1-1[V104] COMPLEXED WITH (9R,10R)-9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHRENE](/index.php/File:PDB_2pgt_EBI.jpg){kind=link}
![3pgt: CRYSTAL STRUCTURE OF HGSTP1-1[I104] COMPLEXED WITH THE GSH CONJUGATE OF (+)-ANTI-BPDE](/index.php/File:PDB_3pgt_EBI.jpg){kind=link}
![4pgt: CRYSTAL STRUCTURE OF HGSTP1-1[V104] COMPLEXED WITH THE GSH CONJUGATE OF (+)-ANTI-BPDE](/index.php/File:PDB_4pgt_EBI.jpg){kind=link}
