GSDMB
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Gasdermin B is a protein that in humans is encoded by the GSDMB gene. [1]
Function
[edit | edit source]This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.
Clinical significance
[edit | edit source]GSDMB expression has been linked to higher survival rates for lung cancer patients.[2]
References
[edit | edit source]Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.