GRAFS
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The GPCR superfamily is the largest gene family in the human genome containing approximately 800 genes.[1] As the vertebrate superfamily can be phylogenetically grouped into five main families the GRAFS classification system has been proposed.
GRAFS stands for Glutamate, Rhodopsin, Adhesion, Frizzled/Taste2, Secretin.[2] They correspond to classical classes C (class C, glutamate), A (rhodopsin-like), B2 (Secretin receptor family, long N-terminal), F (Frizzled/Smoothened), and B1+3 (other secretin).[3] Taste2 has more recently considered to be closer to Rhodopsin-like receptors.[4]
See also
[edit | edit source]References
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