GAS5
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Growth arrest-specific 5 is a non-protein coding RNA that in humans is encoded by the GAS5 gene.[1][2]
GAS5 noncoding RNA, which accumulates in growth arrested cells, acts as a decoy hormone response element for the glucocorticoid receptor (GR) and hence blocks the upregulation of gene expression by activated GR.[3][4]
A number of studies have linked GAS5 to apoptosis and it may play a role in the progression of some types of cancer.[5][6][7]
The GAS5 introns host several snoRNA sequences, including SNORD81, SNORD47, SNORD80, SNORD79, SNORD78, SNORD44, SNORD77, SNORD76, SNORD75 and SNORD74.[2][8][9][10] These intronic sequences are more conserved than the exons of the host gene, these sorts of genes are often called "inside-out genes".[11]
It was recently discovered that the nonsense-mediated degradation pathway can regulate the function of the GAS5 in mammalian cells.[12]
References
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Further reading
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