FOLR3
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Folate receptor gamma is a protein that in humans is encoded by the FOLR3 gene. It is involved in up-take of folic acid.[1]
Gene location
[edit | edit source]The FOLR multi-gene family (FOLR1, FOLR2 and FOLR3) is localized to chromosome 11q13.3–q14.1, and encodes the gene products FRα, β and γ, respectively.[2]
Tissue distribution
[edit | edit source]FOLR3 is localized in haematopoietic tissue, such as spleen and bone marrow, and is present as a secretory protein. FOLR3 expresses in humans rather than mice and rats.[1]
Function
[edit | edit source]The FOLR3 gene is polymorphic due to a nonsense mutation resulting in a truncated protein; FRγ, which can bind folic acid. FOLR3 genes each consist of 5 exons, 4 introns and 1 promoter that encodes a single transcript.[1]
Clinical significance
[edit | edit source]Expression of FOLR3 is correlated more strongly with plasma homocysteine(Hcy) than FOLR1 and FOLR2. FOLR3 may decrease plasma Hcy compared with other FOLRs.[2] It was demonstrated that FOLR3 can metabolize both intracellular Hcy and extracellular Hcy. These results indicate that an increase in FOLR3 may effectively ameliorate Hcy in the blood and weaken Hcy-induced toxicity, even in tissues with the low level of FOLR1 and FOLR2 expression.[2]
