FNBP1L
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Formin-binding protein 1-like is a protein that in humans is encoded by the FNBP1L gene.[1][2]
Function
[edit | edit source]The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.[2]
Clinical significance
[edit | edit source]FNBP1L polymorphisms, specifically the SNP rs236330 has been associated with normally varying intelligence differences in adults[3] and in children.[4]
References
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Further reading
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