FEZ1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Fasciculation and elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene.[1][2][3]
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.[3]
This protein is present in neurons, and it is believed to block the process of infection of these cells by HIV.[4]
Interactions
[edit | edit source]FEZ1 has been shown to interact with Protein kinase Mζ,[5] NBR1[6] and DISC1.[7]
References
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Further reading
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