FAM135B
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). FAM135B is a human gene coding for a protein of unknown function.[1] It is well conserved in primates, rodents, zebra fish. It has one paralog, FAM135A.
Gene
[edit | edit source]FAM135B is located on the long arm of Chromosome 8 in humans on the anti-sense located at 24.23.[1] The following genes are near FAM135B on the chromosome:
- COL22A1: Collagen producing gene that is a cell adhesion ligand for skin epithelial cells and fibroblast
- FLJ45972: Gene function is unknown
- KCNK9: Gene that encodes for a two pore potassium channel
Expression
[edit | edit source]FAM135B is expressed in the brain, ear, eye, pancreas and testis.[2] Within the brain, expression is apparent within the motor nucleus of trigeminal[3] In addition, it is mainly expressed in normal health states, although it has shown moderate expression in glioma, non-neoplasima as well as expression in germ cell tumors.[2]
File:Visual Representation of expression in mouse brain.png
Interactions
[edit | edit source]FAM135B has shown to interact with KAT5, a gene that encodes for a histone acetyltransferase[4] through yeast two-hybrid experimentation.
Protein
[edit | edit source]The protein encoded on FAM135 is 1406 amino acids long. The protein contains a region called DUF676, believed to be a putative serine esterase as well as two protein regions called DUF3657.[1]
Clinical significance
[edit | edit source]FAM135B has shown to be expressed in individuals with extrapulmonary tuberculosis.[5]
References
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- ^ a b EST Profile - Hs.126024
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