Emde degradation
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| Emde degradation | |
|---|---|
| Named after | Hermann Emde |
| Reaction type | Degradation reaction |
| Identifiers | |
| RSC ontology ID | RXNO:0000147 |
The Emde degradation (also called Emde-reaction or Emde-reduction) is a method for the reduction of a quaternary ammonium cation to a tertiary amine with sodium amalgam:[1][2][3]
This organic reaction was first described in 1909 by the German chemist Hermann Emde. It was for a long time of great importance in structure elucidation of many alkaloids, for example that of ephedrine.
Alternative reducing agents exist for this reaction; for instance, lithium aluminium hydride.
See also
[edit | edit source]- Related reactions are the Hofmann elimination and the von Braun reaction
References
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