Elizabeth Nolan
Elizabeth Nolan | |
|---|---|
| Born | Elizabeth Marie Nolan 1978 (age 47–48) |
| Alma mater | Smith College Massachusetts Institute of Technology |
| Awards | PECASE |
| Scientific career | |
| Institutions | Massachusetts Institute of Technology Harvard Medical School |
| Thesis | Fluorescent chemosensors for exploring zinc metalloneurochemistry and detecting mercury in aqueous solution (2006) |
| Doctoral advisor | Stephen J. Lippard |
| Website | chemistry |
Elizabeth Marie Nolan (born 1978) is an American chemist and Ivan R. Cottrell Professor of Immunology in the Department of Chemistry at Massachusetts Institute of Technology.
Early life and education
[edit | edit source]Nolan was born in Niskayuna, New York.[1] She studied at Smith College, where she majored in chemistry and graduated magna cum laude in 2000.[1][2] During her undergraduate studies she minored in music and worked with Robert Linck on computational chemistry.[3] She studied the stereoelectronic effects in substituted alkanes.[4] Nolan was a member of Phi Beta Kappa.[1] She was awarded a Fulbright Program Scholarship and moved to France to study siderophore-iron complexes.[2] Nolan moved to Massachusetts Institute of Technology for her graduate studies, where she was supervised by Stephen J. Lippard.[1] She developed small molecule fluorescent sensors to monitor for zinc in neurobiology and mercury in aqueous solutions.[1][5] Together they filed a patent for Fluorescein-based metal sensors.[6] Nolan was a postdoctoral scientist at the Harvard Medical School, working with Christopher T. Walsh on the biosynthetic assembly of microcin E492m.[7] Microcin E492m is an antibiotic peptide that can target Gram-negative bacteria which express siderophore transporters.[1][7][8] She was awarded a $2.5 million National Institutes of Health grant in 2010 to study antibacterial peptides and zinc in innate immunity.[9] In 2011 she contributed to the book Letters to a Young Chemist.[4][10]
Research and career
[edit | edit source]Nolan was appointed as an assistant professor at the department of chemistry at the Massachusetts Institute of Technology in 2014.[1] She explores the coordination chemistry of metal ions in biological systems; in particular how proteins destroy microbes by denying them metal nutrients.[3][11][12] She looks at the peptides and metalloproteins that are involved in mammalian immune response. Her current focus is on calprotectins and how they bind metals.[13][14] She used magnetic circular dichroism to study the binding of iron to human calprotectin.[15] Her group look to understand how Neuronal cells process and removes SOD1 point mutants.[16]
Nolan looks to design drugs to fight bacterial infections.[11] They study how immunity peptides that are encoded by the gene clusters that biosynthesize antibiotics which use metal ion transporters protect the organisms that produce them.[16] She proposes that hijacking the siderophore uptake pathways could allow new prevention and treatment against diseases.[citation needed] She worked with Manuela Raffatellu at University of California, Irvine to develop a new immunisation strategy against salmonella.[17] They target siderophores, a molecule that salmonella secretes to scavenge iron. Immunisation against siderophores led to the production of antibodies that reduced the growth of salmonella and other bacteria.[18] She is on the editorial board of Cell Chemical Biology.[19]
Patents
[edit | edit source]- 2009 Fluorescein-based metal sensors[6]
- 2015 Enterobactin conjugates and uses thereof[20][21]
- 2016 Siderophore-based immunization against gram-negative bacteria[22][23]
Awards and honours
[edit | edit source]- 2010 National Institutes of Health New Innovator Award[24]
- 2011 Searle Scholar[16]
- 2014 National Science Foundation CAREER Award
- 2014 Camille Dreyfus Teacher-Scholar
- 2016 Eli Lilly Award in Biological Chemistry[25]
- 2016 Massachusetts Institute of Technology School of Science Teaching Prize[26]
- 2017 Loyola University Chicago Denkewalter Lecture[27]
- 2017 Presidential Early Career Award for Scientists and Engineers[28]
References
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- 1978 births
- Massachusetts Institute of Technology School of Science faculty
- Massachusetts Institute of Technology School of Science alumni
- Smith College alumni
- American women biochemists
- Living people
- 21st-century American women scientists
- Chemists from New York (state)
- Recipients of the Presidential Early Career Award for Scientists and Engineers
- 21st-century American women academics
- 21st-century American academics