Eggerthellaceae

Eggerthellaceae
Scientific classification
Domain:	Bacteria
Kingdom:	Bacillati
Phylum:	Actinomycetota
Class:	Coriobacteriia
Order:	Eggerthellales Gupta et al. 2013
Family:	Eggerthellaceae Gupta et al. 2013
Genera
See text

The Eggerthellaceae are a family of Gram-positive, rod- or coccus-shaped Actinomycetota. It is the sole family within the order Eggerthellales.

The name Eggerthellaceae is derived from the Latin term Eggerthella, referring to the type genus of the family and the suffix "-ceae," an ending used to denote a family. Together, Eggerthellaceae refers to a family whose nomenclatural type is the genus Eggerthella.

Biochemical characteristics and molecular signatures

Members of this family are mostly anaerobic, non-motile (with the exception of some Gordonibacter and Senegalimassilia species that exhibit motility), asaccharolytic and do not form spores. Eggerthellaceae species are commonly isolated from human and animal faeces and other human sources such as the colon, vagina, oral cavity and blood. Some species have also been isolated from human samples of periodontal or endodontic infections, Crohn's disease and severe blood bacteremia. The G+C content for Eggerthellaceae species is between 43.4 and 66.3 mol%.

Analysis of genome sequences identified 13 conserved signature indels (CSIs) in diverse proteins that are exclusively present in different Eggerthellaceae species. The proteins containing these CSIs are: excinuclease ABC subunit UvrC, DNA polymerase III subunit alpha, ribonuclease III, tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase (MiaB), peptide chain release factor 2, 16S rRNA (cytosine(1402)-N(4))-methyltransferase, elongation factor Tu, UDP-N-acetylglucosamine 1-carboxyvinyltransferase DNA polymerase III subunit epsilon, UDP-glucose 4-epimerase and DNA-directed RNA polymerase subunit alpha. The identified CSIs provide reliable and important means to distinguish members of Eggerthellaceae from all other Coriobacteriia as well as other bacteria.

Phylogeny

The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN) and National Center for Biotechnology Information (NCBI).

Nouioui et al. 2018	conserved signature indels by Gupta & Carro 2021
Coriobacteriales Eggerthellales Slackia Cryptobacterium Denitrobacterium Senegalimassilia Eggerthella Gordonibacter Adlercreutzia	"

16S rRNA based LTP_10_2024

120 marker proteins based GTDB 09-RS220

Eggerthellaceae~ Anaerotardibacter Raoultibacter Atopobiaceae Eggerthellaceae~ Cryptobacterium Curtanaerobium Denitrobacterium Slackia Coriobacteriaceae Eggerthellaceae Ellagibacter Senegalimassilia Berryella Adlercreutzia [incl. Parvibacter] Rubneribacter Xiamenia Adlercreutzia agrestimuris Afrizal et al. 2023 Enteroscipio Arabiibacter Paraeggerthella Gordonibacter Eggerthella

Eggerthellaceae "Phoenicibacter" Bilen et al. 2019 Slackia Wade et al. 1999 Anaerotardibacter Afrizal et al. 2024 Cryptobacterium Nakazawa et al. 1999 "Hugonella" Elsawi et al. 2017 Curtanaerobium Sun et al. 2023 Denitrobacterium Anderson et al. 2000 Berryella Wylensek et al. 2021 "Adlercreutzia murintestinalis" Afrizal et al. 2022 Parvibacter Clavel et al. 2013 Adlercreutzia Maruo et al. 2008 "Ca. Aveggerthella" Gilroy et al. 2021 Raoultibacter Traore et al. 2022 "Ca. Aphodovivens" Gilroy et al. 2021 Ellagibacter Beltran et al. 2018 Senegalimassilia corrig. Lagier et al. 2014 Xiamenia Zhang et al. 2022 Gordonibacter Wurdemann et al. 2009 Enteroscipio Danylec et al. 2018 Arabiibacter Lo et al. 2023 Rubneribacter Danylec et al. 2018 Paraeggerthella Wurdemann et al. 2009 Eggerthella Wade et al. 1999 Coriobacteriaceae Atopobiaceae