Edna Cukierman

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Eti Cukierman
אתי קוקיירמן
File:Edna Cukierman CDMRP photo.jpg
Cukierman in a Congressionally Directed Medical Research Programs (CDMRP) photo, 2018
Born
Edna Cukierman

Mexico City
Alma materTechnion – Israel Institute of Technology
Scientific career
FieldsTumor microenvironment
Cancer associated fibroblasts
Extracellular matrix
Pancreatic cancer
Desmoplasia[1]
InstitutionsNational Institute of Dental and Craniofacial Research
Fox Chase Cancer Center
ThesisMolecular characterization of an ARF directed GTPase activating protein (1997)
Doctoral studentsJaye Gardiner

Edna "Eti" Cukierman (Hebrew: עדנה "אתי" צוקירמן) is a Mexican biochemist who is a professor at the Fox Chase Cancer Center.[1][2] She serves as co-director of the Marvin & Concetta Greenberg Pancreatic Cancer Institute. Her research investigates pancreatic cancer and the tumor microenvironment.

Early life and education

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Cukierman was born in Mexico City.[3] She emigrated to Israel in 1986.[3] She joined Technion – Israel Institute of Technology for her doctoral research, where she studied ARF directed GTPase.[4][5]

Research and career

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After her PhD, Cukierman was awarded a postdoctoral fellowship in 1997, and joined the National Institute of Dental and Craniofacial Research.[3] She developed a multilayered fibroblastic cell-derived extracellular matrix, which became widely used in biomaterials research.[6][7]

Cukierman joined the Fox Chase Cancer Center in 2002.[3] She studies pancreatic cancer, with a specific focus on the tumor microenvironment and the identification of strategies that can change the tumor microenvironment.[8] Desmoplasia, which is the growth of connective tissue, shows similarities to wound healing pathologies (e.g. chronic inflammation).[9][10] She believes it will be possible to stall the growth of tumors by transforming the microenvironment into one which harnesses anti-tumor functions.[11]

In 2005, Cukierman demonstrated that desmoplastic extracellular matrices could induce a myofibroblastic phenotype on naïve fibroblastic cells.[12] This work involved the realization of a human mimetic three-dimensional stroma system, which allowed Cukierman to understand the extracellular factors that determine the function of fibroblasts.[12] Through multi-cellular culturing, Cukierman has shown how cancer-associated fibroblasts impart immunosuppressive influences, communicate and provide nutrition to cancer cells.[12] She identified that cancer communication involved the TGF beta signaling pathway, extracellular matrix and integrin signalling pathway and the reorganization of cytoskeletal elements.[13] She demonstrated that the glutamatergic presynaptic protein Netrin G1 promoted tumorgenesis by providing nutritional support and immunity to cancer-associated fibroblasts.[14] She has shown that anti-Netrin G1 antibodies can halt tumorgenesis.[9]

Cukierman joined the American Gastroenterological Association in 2010.[8] At the time, this was considered novel because the association is mainly a medical association, and Cukierman is not a physician.[8] In 2017, she established the Marvin and Concetta Greenberg Pancreatic Cancer Institute.[15]

Awards and honors

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Academic service

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Cukierman has supported the development of early career researchers, and has developed a philosophy around teaching and mentoring. She is a member of the American Cancer Society, and on the editorial board of Matrix Biology.[19]

Selected publications

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  • Taking cell-matrix adhesions to the third dimension[20]
  • Modeling tissue morphogenesis and cancer in 3D[21]
  • A framework for advancing our understanding of cancer-associated fibroblasts[22]

References

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