Dibutyl squarate

Dibutyl squarate

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Names
IUPAC name 3,4-Dibutoxy-3-cyclobutene-1,2-dione
Other names Squaric acid dibutyl ester; SADBE
Identifiers
CAS Number	2892-62-8 checkY
3D model (JSmol)	Interactive image
Beilstein Reference	1968189
ChEBI	CHEBI:53612
ChEMBL	ChEMBL2435707
ChemSpider	58618
DrugBank	DB12223
ECHA InfoCard
EC Number	628-906-7
E number
PubChem CID	65108
UNII	4RTO57VG65
CompTox Dashboard (EPA)	{{#property:P3117}}
InChI InChI=1S/C12H18O4/c1-3-5-7-15-11-9(13)10(14)12(11)16-8-6-4-2/h3-8H2,1-2H3 Key: XBRWELTXMQSEIN-UHFFFAOYSA-N
SMILES CCCCOC1=C(C(=O)C1=O)OCCCC
Properties
Chemical formula	C12H18O4
Molar mass	226.272 g·mol−1
Hazards
GHS labelling:
Pictograms	GHS07: Exclamation mark
Signal word	Warning
Hazard statements	H315, H317, H319, H335
Precautionary statements	P261, P264, P264+P265, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P313, P337+P317, P362+P364, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Dibutyl squarate (also known as squaric acid dibutyl ester or SADBE) is a chemical compound with the molecular formula C₁₂H₁₈O₄. It is the dibutyl derivative of squaric acid.

Medically, it is used for the treatment of warts and for treating alopecia areata or alopecia totalis (autoimmune hair loss) through topical immunotherapy involving the production of an allergic rash. Dibutyl squarate is currently undergoing trials for use in treating herpes labialis (cold sores).