DPH5
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Diphthine synthase is an enzyme that in humans is encoded by the DPH5 gene.[1][2]
This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis.
The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.[2]
References
[edit | edit source]Further reading
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