DEPDC7
DEP Domain Containing Protein 7 (DEPDC7) is a protein of unknown function located on chromosome 11 bases 33,015,863-33,033,581.[1] The cytogenetic location is 11p13.[1] DEPDC7 has several aliases: DEP Domain Containing 7, DJ85M6.4, Novel 58.3 KDA Protein, Protein TR2/D15, and TR2.[2] The DEPDC7 gene is 17,718 base pairs long and has 8 exons and 9 introns.[3] The gene is capable of making 6 different mRNA transcripts.[3] Two functional domains can be found within this gene's sequence: DEP (Dishevelled, Egl-10, and Pleckstrin) domain and RhoGAP domain.[4]
mRNA
[edit | edit source]Transcription produces 4 alternatively spliced variants and 2 unspliced forms.[3] Isoform 1 is the longest of all the variants containing all 8 exons.[4] It codes for 511 amino acids.[4] Northern blot analysis detected that the DEPDC7 transcript in humans was expressed highly in the liver and moderately expressed in the kidney.[1] Hypomethylation of one of the DEPDC7 introns was related to the appearance of depression symptoms.[5]
Protein
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The protein is 511 amino acids long and has a molecular weight of 58310.[6] DEPDC7 could have a role in tumor suppression. Overexpression inhibits the proliferation of hepatoma cells blocks the cell cycle transition from the G0/G1 to S phase, and inhibits the migration and invasion of hematoma cells.[7] DEPDC7 could potentially regulate neural development and physiology and could participate in epigenetic processes of striatal neurons.[8] Genomic rearrangement within 11p12 and 11p14 were associated with WAGR syndrome.[9]
DEP Domain
[edit | edit source]DEP domain is named after the 3 proteins it was initially found in: Dishevelled, Egl-10, and Pleckstrin.[3] Dishevelled plays a key role in the transduction of the Wg/Wnt signal.[3] This signal goes from the cell surface to the nucleus.[3] Dishevelled is a segment polarity protein needed to make coherent arrays of polarized cells and segments in embryos.[3] It also plays a role in wingless signaling. Egl-10 regulates G-protein signaling in the central nervous system.[3] Pleckstrin has 2 PH domains flanking the DEP domain and is the major substrate of protein kinase C in platelets.[3] The DEP domain within DEPDC7 was found to bind with CARMA2 and CARMA3 proteins.[10]
Paralog
[edit | edit source]DEPDC7 has a paralog: DEPDC1B, a protein coding gene.
References
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