DCP1A
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). mRNA-decapping enzyme 1A is a protein that in humans is encoded by the DCP1A gene.[1]
Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.[1]
Interactions
[edit | edit source]DCP1A has been shown to interact with DCP2[2] and UPF1.[2] It has also been shown to colocalize with GW182, and other markers of P-body.[3] Human DCP1A is heterotrimeric,[4] and makes contacts with the scaffold EDC3/4.[5] The Arabidopsis thaliana homolog interacts with the plant specific type XI myosin motor protein.[6]
References
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Further reading
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