Chuan He

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The native form of this personal name is He Chuan. This article uses Western name order when mentioning individuals.
Chuan He
File:Chuan He in 2025 by Christopher Michel 02.jpg
Chuan He in 2025
Born1972 (age 53–54)
Guizhou, China
Alma materUniversity of Science and Technology of China (B.S.)
Massachusetts Institute of Technology (Ph.D.)
Known forEpigenetics, DNA Methylation
AwardsSearle Scholar Award (2003)
Beckman Young Investigators Award (2005)
Paul Marks Prize for Cancer Research (2017)
ACS Chemical Biology Lectureship (2019)
Wolf Prize in Chemistry (2023)
Scientific career
FieldsChemical Biology, Genetics
InstitutionsUniversity of Chicago
Doctoral advisorStephen J. Lippard
Other academic advisorsGregory L. Verdine
Doctoral studentsXiao Wang

Chuan He (Chinese: 何川) is a Chinese-American chemical biologist. He currently serves as the John T. Wilson Distinguished Service Professor at the University of Chicago, and an Investigator of the Howard Hughes Medical Institute.[1] He is best known for his work in discovering and deciphering reversible RNA methylation in post-transcriptional gene expression regulation.[2] He was awarded the 2023 Wolf Prize in Chemistry for his work in discovering and deciphering reversible RNA methylation in post-transcriptional gene expression regulation in addition to his contributions to the invention of TAB-seq, a biochemical method that can map 5-hydroxymethylcytosine (5hmC) at base-resolution genome-wide, as well as hmC-Seal, a method that covalently labels 5hmC for its detection and profiling.[2]

Education

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He graduated from the University of Science and Technology of China in 1994 with a Bachelor of Science in Chemistry. After undergoing his Ph.D. training with Stephen J. Lippard at the Massachusetts Institute of Technology, he worked under Gregory L. Verdine as a Damon Runyon Postdoctoral Fellow at Harvard University. He subsequently became a faculty member in the Department of Chemistry at the University of Chicago in 2002.[3]

Research

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In 2010, He proposed that RNA modifications could be reversible and may have regulatory roles.[2] He and colleagues subsequently discovered the first RNA demethylase that oxidatively reverses N6-methyladenosine (m6A) methylation in mammalian messenger RNA (mRNA) in 2011.[4] The existence of m6A in mRNA was discovered in 1974 in both eukaryotic and viral mRNAs; however, the biological significance and functional role were not known before He’s work. This methylation is the most abundant internal modification in mammalian mRNA. In 2012, two independent studies reported transcriptome-wide mapping of m6A in mammalian cells and tissues,[5][6] revealing a unique distribution pattern. He and co-workers identified and characterized the direct reader proteins for m6A, which impact the stability and the translation efficiency of m6A-modified mRNA, elucidating functional roles of mRNA methylation.[7][8] His group also purified the methyltransferase complex that mediates this methylation.[9]

The He laboratory also studies DNA methylation. He invented TAB-seq, a method that can map 5-hydroxymethylcytosine (5hmC) at base-resolution genome-wide, as well as hmC-Seal, a method that covalently labels 5hmC for its detection and profiling.[10][11] Together with two other research groups, He and co-workers have revealed the DNA N6-methyldeoxyadenosine as a new methylation mark that could affect gene expression in eukaryotes.[12][13][14]

Honors and awards

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References

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  1. ^ Chuan He Profile at the Howard Hughes Medical Institute hhmi.org Retrieved 07-28-2015
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  3. ^ Chuan He Faculty Page at the University of Chicago chemistry.uchicago.edu Retrieved 07-28-2015
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  19. ^ Wolf Prize in Chemistry 2023
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