Calcium D-glucarate

Calcium D-glucarate

Names
Other names Calcium d-saccharate, Antacidin
Identifiers
CAS Number	5793-88-4 tetrahydrate: 5793-89-5
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL2104217
ChemSpider	136477 tetrahydrate: 10128632
DrugBank	DB13962
ECHA InfoCard
EC Number	227-334-1 tetrahydrate: 611-592-0
E number
KEGG	tetrahydrate: D03307
PubChem CID	154911 tetrahydrate: 11954337
UNII	SST07NLK7J tetrahydrate: 6AP9J91K4V
CompTox Dashboard (EPA)	{{#property:P3117}}
InChI InChI=1S/C6H10O8.Ca/c7-1(3(9)5(11)12)2(8)4(10)6(13)14;/h1-4,7-10H,(H,11,12)(H,13,14);/q;+2/p-2/t1-,2-,3-,4+;/m0./s1 Key: UGZVNIRNPPEDHM-SBBOJQDXSA-L tetrahydrate: InChI=1S/C6H10O8.Ca.4H2O/c7-1(3(9)5(11)12)2(8)4(10)6(13)14;;;;;/h1-4,7-10H,(H,11,12)(H,13,14);;4*1H2/q;+2;;;;/p-2/t1-,2-,3-,4+;;;;;/m0...../s1 Key: ZQWFSIZRQANUDA-WQMSYZFBSA-L
SMILES [C@H]([C@@H]([C@@H](C(=O)[O-])O)O)([C@H](C(=O)[O-])O)O.[Ca+2]
Properties
Chemical formula	C6H8CaO8
Molar mass	248.200 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Calcium D-glucarate (or calcium saccharate) is the calcium salt of D-glucaric acid (saccharic acid), a substance naturally found in small amounts in fruits and vegetables such as oranges, apples, grapefruits, and cruciferous vegetables. It is commonly used as a dietary supplement, primarily marketed for its potential role in supporting detoxification processes and hormone regulation. Preclinical studies suggest that calcium D-glucarate may possess anticarcinogenic properties and improve detoxification markers, but more definitive clinical research such as a randomized controlled trial is needed to verify health claims.

Structure and chemistry

Calcium D-glucarate is composed of calcium bound to D-glucaric acid, a derivative of glucose metabolism. D-Glucaric acid itself is classified as a sugar acid, and when bonded with calcium, it forms a more stable compound suitable for supplementation.

Biological activity

In the body, calcium D-glucarate is hydrolyzed to release D-glucaric acid, which can be further metabolized into compounds such as D-glucaro-1,4-lactone. These metabolites are known to inhibit the enzyme beta-glucuronidase. Beta-glucuronidase is involved in the breakdown of glucuronides in the liver and intestines, a process that can release potentially harmful compounds back into circulation.

By inhibiting beta-glucuronidase, calcium D-glucarate is thought to promote the excretion of carcinogens, steroid hormones (such as estrogen), and other potentially toxic substances bound for elimination through the bile and urine.

Simulations suggest other mechanisms of detoxification such as inhibiting the production of reactive oxygen species, lowering deglucuronidation activity which would otherwise prevent the elimination of toxic substances from the body, or suppressing hepatocyte apoptosis. However, in vivo research is needed to verify the occurrence of such mechanistic pathways in humans.

Dietary sources

Although calcium D-glucarate itself is not abundant in foods, D-glucaric acid is naturally present in fruits and vegetables. Foods with notable amounts include:

• Oranges
• Apples
• Grapefruit
• Broccoli
• Brussels sprouts

Supplement use

Calcium D-glucarate is available as an over-the-counter dietary supplement, typically in capsule or tablet form. Dosages used in supplements generally range from 200 mg to 1000 mg per serving.

Safety and side effects

Calcium D-glucarate appears to be well tolerated in humans when used at typical supplemental doses. Reported side effects are rare but may include mild gastrointestinal discomfort. No major toxicity concerns have been identified in available studies, although long-term human research is limited.

See also

• Saccharic acid
• Glucuronidation