COG4
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Conserved oligomeric Golgi complex subunit 4 is a protein that in humans is encoded by the COG4 gene.[1][2]
Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG4 (Ungar et al., 2002).[supplied by OMIM][2]
Interactions
[edit | edit source]COG4 has been shown to interact with COG7,[3] COG2,[3] COG1[3] and COG5.[3]
Clinical
[edit | edit source]Mutations in this gene have been associated with Saul-Wilson syndrome.[4]
References
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- ^ Ferreira C (2020) Saul-Wilson syndrome. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. SourceGeneReviews. Seattle (WA): University of Washington, Seattle
Further reading
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External links
[edit | edit source]- GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
- Human COG4 genome location and COG4 gene details page in the UCSC Genome Browser.
