CLK1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.[1][2]
Function
[edit | edit source]This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the cell nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine-rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection.[2]
Interactions
[edit | edit source]CLK1 has been shown to interact with ASF/SF2.[3][4]
References
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External links
[edit | edit source]- Human CLK1 genome location and CLK1 gene details page in the UCSC Genome Browser.
Further reading
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