CDKN2BAS
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| CDKN2B antisense RNA 1 intronic convserved region | |
|---|---|
 Predicted secondary structure and sequence conservation of CDKN2B-AS | |
| Identifiers | |
| Symbol | CDKN2B-AS |
| Alt. Symbols | ANRIL |
| Rfam | RF01909 |
| Other data | |
| RNA type | Gene; |
| Domain | Eukaryota; |
| GO | GO:0006342 GO:0005515 |
| SO | SO:0001463 |
| PDB structures | PDBe |
CDKN2B-AS, also known as ANRIL (antisense non-coding RNA in the INK4 locus) is a long non-coding RNA consisting of 19 exons, spanning 126.3kb in the genome, and its spliced product is a 3834bp RNA. It is located within the p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the antisense direction. Single nucleotide polymorphisms (SNPs) which alter the expression of CDKN2B-AS are associated with human healthy life expectancy, as well as with multiple diseases, including coronary artery disease, diabetes and many cancers.[1] It binds to chromobox 7 (CBX7) within the polycomb repressive complex 1 and to SUZ12, a component of polycomb repression complex 2 and through these interactions is involved in transcriptional repression.[2][3]
See also
[edit | edit source]References
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Further reading
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External links
[edit | edit source]- Page for CDKN2B antisense RNA 1 intronic conserved region at Rfam
- Human CDKN2B-AS genome location and CDKN2B-AS gene details page in the UCSC Genome Browser.
- Human CDKN2B-AS1 genome location and CDKN2B-AS1 gene details page in the UCSC Genome Browser.