CDC42EP2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.[1][2][3]
Function
[edit | edit source]CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.[3]
Interactions
[edit | edit source]CDC42EP2 has been shown to interact with CDC42[1][2] and RHOQ.[1]
References
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External links
[edit | edit source]- Human CDC42EP2 genome location and CDC42EP2 gene details page in the UCSC Genome Browser.
Further reading
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