CDC37

Cdc37 N terminal kinase binding
Identifiers
Symbol	CDC37_N
Pfam	PF03234
InterPro	IPR013855
SCOP2	1us7 / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Cdc37 Hsp90 binding domain
File:PDB 1us7 EBI.jpg complex of hsp90 and p50
Identifiers
Symbol	CDC37_M
Pfam	PF08565
InterPro	IPR013874
SCOP2	1us7 / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Cdc37 C terminal domain
File:PDB 1us7 EBI.jpg complex of hsp90 and p50
Identifiers
Symbol	CDC37_C
Pfam	PF08564
InterPro	IPR013873
SCOP2	1us7 / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene. This protein is highly similar to Cdc 37, a cell division cycle control protein of Saccharomyces cerevisiae. This protein is a HSP90 Co-chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK, as well as eIF-2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.

Interactions

CDC37 has been shown to interact with:

• CDK4,
• HSP90AA1
• IKBKG,
• IKK2, and
• STK11.

Domain architecture

CDC37 consists of three structural domains. The N-terminal domain binds to protein kinases. The central domain is the Hsp90 chaperone (heat shock protein 90) binding domain. The function of the C-terminal domain is unclear.

External links

• Human CDC37 genome location and CDC37 gene details page in the UCSC Genome Browser.

This article incorporates text from the public domain Pfam and InterPro: IPR013855

This article incorporates text from the public domain Pfam and InterPro: IPR013874

This article incorporates text from the public domain Pfam and InterPro: IPR013873