CD200R1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene.[1][2][3] CD200R1 is expressed on the surface of myeloid cells[4] and CD4+ T cells.[5] It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons,[6] epithelial cells,[7] endothelial cells,[8] fibroblasts,[9] and lymphoid cells.[10]
CD200R1 activation regulates the expression of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha),[11] interferons, and inducible nitric oxide synthase (iNOS).[12]
Function
[edit | edit source]This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.[3]
References
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Further reading
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External links
[edit | edit source]- CD200R1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CD200R1 genome location and CD200R1 gene details page in the UCSC Genome Browser.
- Human HCRTR2 genome location and HCRTR2 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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