CCRL2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). C-C chemokine receptor-like 2 is a protein that in humans is encoded by the CCRL2 gene.[1][2] Recently it was found that CCRL2 also acts as a receptor for the chemokine chemerin.[3]
Function
[edit | edit source]This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.[2]
References
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External links
[edit | edit source]- Human CCRL2 genome location and CCRL2 gene details page in the UCSC Genome Browser.
Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
