CCNB1IP1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). E3 ubiquitin-protein ligase CCNB1IP1 is an enzyme that in humans is encoded by the CCNB1IP1 gene.[1][2]
HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM][2] It is considered a housekeeping gene.
During meiosis, crossing over between homologous chromosomes (homologs) facilitates accurate chromosome segregation.[3] In mammals, the ring-domain protein CCNB1IP1, also known as HEI10, promotes crossing over between each pair of homologs during meiosis.[3] Studies in the mouse showed that this pro-crossover ring-domain protein facilitates the homologous recombination and DNA repair processes that produce crossovers.[3]
References
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External links
[edit | edit source]- Human CCNB1IP1 genome location and CCNB1IP1 gene details page in the UCSC Genome Browser.
Further reading
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