Baxdrostat
| File:Baxdrostat.svg | |
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| E number | {{#property:P628}} |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
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| Formula | C22H25N3O2 |
| Molar mass | 363.461 g·mol−1 |
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Baxdrostat is an investigational drug that is being evaluated for the treatment of hypertension.[1] It is an aldosterone synthase inhibitor.[2][3]
Mechanism of action
[edit | edit source]Aldosterone dysregulation contributes significantly to the pathogenesis of resistant hypertension.[4] While conventional drugs act by blocking the mineralocorticoid receptor, baxdrostat, an aldosterone synthase inhibitor, targets the aldosterone synthesis directly. [2]
Clinical trials
[edit | edit source]BrigHTN
[edit | edit source]In adults with treatment-resistant hypertension, treatment with baxdrostat at doses of 1 mg or 2 mg daily produced significantly greater reductions in systolic blood pressure over 12 weeks compared to placebo.[5]
BaxHTN
[edit | edit source]BaxHTN is a phase 3 trial.[6] It found that adding once-daily baxdrostat to standard antihypertensive therapy led to significantly greater reductions in seated systolic blood pressure at 12 weeks compared with placebo, in adults with uncontrolled or resistant hypertension. [7][6]
References
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