BRD2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Bromodomain-containing protein 2 is a protein that in humans is encoded by the BRD2 gene. BRD2 is part of the Bromodomain and Extra-Terminal motif (BET) protein family that also contains BRD3, BRD4, and BRDT in mammals [1][2][3]
Early descriptions demonstrated that BRD2 gene product is a mitogen-activated kinase which localizes to the nucleus. The gene maps to the major histocompatibility complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human gene may be part of a signal transduction pathway involved in growth control.[3]
Functions
[edit | edit source]- BRD2 has been implicated in cancer.[1][4]
- BRD2 loss in mice causes obesity without diabetes for unknown reasons.[1]
- BRD2 may have functional overlap with close homolog BRD3.[5]
- BRD2 function is blocked by BET inhibitors.
Interactions
[edit | edit source]BRD2 has been shown to interact with E2F2,[6][7] and many transcription factors including GATA1.[5]
References
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External links
[edit | edit source]- Human BRD2 genome location and BRD2 gene details page in the UCSC Genome Browser.
Further reading
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