BCCIP
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in humans.[1][2][3]
This gene product was isolated based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.[3]
Interactions
[edit | edit source]BCCIP has been shown to interact with BRCA2,[1] P21,[2] and PTPmu (PTPRM)[4]
References
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External links
[edit | edit source]- Human BCCIP genome location and BCCIP gene details page in the UCSC Genome Browser.
Further reading
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