BAZ1A
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Bromodomain adjacent to zinc finger domain protein 1A is a protein that in humans is encoded by the BAZ1A gene.[1][2]
Structure
[edit | edit source]The protein encoded by this gene belongs to a family of proteins which includes BAZ1B, BAZ2A, and BAZ2B. All family members contain the following domains and structural motifs:[1]
- N-terminus – PHD finger (C4HC3 zinc finger)
- WAKZ motif
- LH (leucine-rich helical domain) motif
- C-terminus – bromodomain
Function
[edit | edit source]BAZ1A along with SMARCA5, POLE3, and CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex.[3][4]
The purified CHRAC complex can mobilize nucleosomes into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent.[4] Furthermore, the BAZ1A-SMARCA5 complex enables DNA replication through highly condensed regions of chromatin.[5]
Interactions
[edit | edit source]BAZ1A has been shown to interact with SMARCA5[3][4][6][7][8] and SATB1.[7]
References
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