BAG2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene.[1][2]
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.[2]
Interactions
[edit | edit source]BAG2 has been shown to interact with HSPA8.[1]
References
[edit | edit source]External links
[edit | edit source]- Human BAG2 genome location and BAG2 gene details page in the UCSC Genome Browser.
Further reading
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