BACE1-AS
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value).
BACE1-AS, also known as BACE1 antisense RNA (non-protein coding), is a human gene at 11q23.3 encoding a long noncoding RNA molecule. It is transcribed from the opposite strand to BACE1 and is upregulated in patients with Alzheimer's disease.[1] BACE1-AS regulates the expression of BACE1 by increasing BACE1 mRNA stability and generating additional BACE1 through a post-transcriptional feed-forward mechanism. By the same mechanism it also raises concentrations of beta amyloid, the main constituent of senile plaques. BACE1-AS concentrations are elevated in subjects with Alzheimer's disease and in amyloid precursor protein transgenic mice.
Knocking down BACE1-AS reduces amyloid production and plaque deposition.[2]
References
[edit | edit source]External links
[edit | edit source]- Human BACE1-AS genome location and BACE1-AS gene details page in the UCSC Genome Browser.