Azzopardi phenomenon
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The Azzopardi phenomenon, or Azzopardi effect, is the presence of DNA in necrotic venules.[1] It can occur in small cell carcinomas and in some high-grade malignant neoplasms.[1][2] The effect is well known in diagnostic surgical pathology.[3] The phenomenon is named after the pathologist, John G. Azzopardi.[4][5][6]
Azzopardi was able to correctly characterize the effect as due to DNA; it had been thought previously but incorrectly to be calcium.[4] Necrosis results in the release of cellular DNA, which adheres in patches to the walls of blood vessels, showing as intensely basophilic material on hematoxylin-eosin stain.[1]
References
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External links
[edit | edit source]- Warnock ML, McCowin MJ in Practical Pathology of Chest Disease--Case Studies
- Azzopardi phenomenon in a metastatic small cell carcinoma of the lung