Azeliragon

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Azeliragon
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Names
IUPAC name
3-[4-[2-butyl-1-[4-(4-chlorophenoxy)phenyl]imidazol-4-yl]phenoxy]-N,N-diethylpropan-1-amine
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
DrugBank
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EC Number
  • 814-441-9
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KEGG
UNII
  • {{#property:P3117}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
  • InChI=1S/C32H38ClN3O2/c1-4-7-9-32-34-31(25-10-16-28(17-11-25)37-23-8-22-35(5-2)6-3)24-36(32)27-14-20-30(21-15-27)38-29-18-12-26(33)13-19-29/h10-21,24H,4-9,22-23H2,1-3H3
    Key: KJNNWYBAOPXVJY-UHFFFAOYSA-N
  • CCCCC1=NC(=CN1C2=CC=C(C=C2)OC3=CC=C(C=C3)Cl)C4=CC=C(C=C4)OCCCN(CC)CC
Properties
C32H38ClN3O2
Molar mass 532.13 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Azeliragon (TTP488 or PF-04494700) is a small-molecule RAGE inhibitor. It is developed by vTv Therapeutics for various cancers, including triple-negative breast cancer[1][2] and pancreatic cancer.[3]

The chemical reached Phase III trials in slowing cognitive deterioration in early stage Alzheimer's disease patients.[4][5][6] It was also tested in people with diabetic neuropathy[7] and animal models of graft-vs-host disease.[8]

References

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