Nizatidine
| File:Nizatidine.svg | |
| Clinical data | |
|---|---|
| Trade names | Axid, Tazac |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a694030 |
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| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Bioavailability | >70% |
| Protein binding | 35% |
| Metabolism | Liver |
| Elimination half-life | 1–2 hours |
| Excretion | Kidney |
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| E number | {{#property:P628}} |
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| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C12H21N5O2S2 |
| Molar mass | 331.45 g·mol−1 |
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Nizatidine is a histamine H2 receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.[2]
It was patented in 1980 and approved for medical use in 1988.[3][4] It was developed by Eli Lilly.
Medical use
[edit | edit source]Nizatidine is used to treat duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD/GORD), and to prevent stress ulcers.[5]
Adverse effects
[edit | edit source]Side effects are uncommon, usually minor, and include diarrhea, constipation, fatigue, drowsiness, headache, and muscle aches.[5]
History and development
[edit | edit source]Nizatidine was developed by Eli Lilly, and was first marketed in 1988.[3] It is considered to be equipotent with ranitidine and differs by the substitution of a thiazole ring in place of the furan ring in ranitidine. In September 2000, Eli Lilly announced they would sell the sales and marketing rights for Axid to Reliant Pharmaceuticals.[6] Subsequently, Reliant developed the oral solution of Axid, marketing this in 2004, after gaining approval from the U.S. Food and Drug Administration (FDA).[7] However, a year later, they sold rights of the Axid Oral Solution (including the issued patent[8] protecting the product) to Braintree Laboratories.[9]
Society and culture
[edit | edit source]Brand names
[edit | edit source]
Brand names include Tazac and Axid.
References
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