Arotinoid acid

Arotinoid acid
	File:Arotinoid acid.svg
Identifiers
	IUPAC name 4-[(E)-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]benzoic acid;
CAS Number	71441-28-6;
PubChem CID	5289501;
IUPHAR/BPS	2646;
DrugBank	DB02877;
ChemSpider	4451454;
UNII	673M8C29UR;
KEGG	C15634;
ChEBI	CHEBI:75261;
ChEMBL	ChEMBL275311;
E number	{{#property:P628}}
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ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C24H28O2
Molar mass	348.486 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C/C(=C\C1=CC=C(C=C1)C(=O)O)/C2=CC3=C(C=C2)C(CCC3(C)C)(C)C;
	InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+; Key:FOIVPCKZDPCJJY-JQIJEIRASA-N;

Arotinoid acid (TTNPB, Ro 13-7410) is an experimental drug which is a synthetic retinoid derivative. It was originally developed for potential medical applications in cancer treatment, but was not adopted due to potent teratogenic activity. However it has since been found to be useful as part of a cocktail of signalling factors used for cellular reprogramming in order to produce pluripotent stem cells.^[1]^[2]^[3]

References

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[3]

v t e Retinoid receptor modulators
RARTooltip Retinoic acid receptor	Agonists: 9CDHRA 9-cis-Retinoic acid (alitretinoin) AC-261066 AC-55649 Acitretin Adapalene Arotinoid acid all-trans-Retinoic acid (tretinoin) AM-580 BMS-493 BMS-753 BMS-961 CD-1530 CD-2314 CD-437 Ch-55 EC 23 Etretinate Fenretinide Isotretinoin Palovarotene Retinoic acid Retinol (vitamin A) Tamibarotene Tazarotene Tazarotenic acid Trifarotene Antagonists: BMS-195614 BMS-493 CD-2665 ER-50891 LE-135 MM-11253 Retinoic acid metabolism inhibitors: Liarozole Talarozole
RXRTooltip Retinoid X receptor	Agonists: 9CDHRA 9-cis-Retinoic acid (alitretinoin) all-trans-Retinoic acid (tretinoin) Bexarotene CD 3254 Docosahexaenoic acid Fluorobexarotene Isotretinoin LG-100268 LG-101506 LG-100754 Retinoic acid Retinol (vitamin A) SR-11237 Antagonists: HX-531 HX-630 LG-100754 PA-452 UVI-3003 HX-603 LE135 (RAR beta selective) LE-540 CD3254 PA-451 PA-452 Rhein HX-711 6-(N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino)nicotinic acid
See also Receptor/signaling modulators

Identifiers
File:Arotinoid acid.svg
IUPAC name 4-[(E)-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]benzoic acid
CAS Number	71441-28-6
PubChem CID	5289501
IUPHAR/BPS	2646
DrugBank	DB02877
ChemSpider	4451454
UNII	673M8C29UR
KEGG	C15634
ChEBI	CHEBI:75261
ChEMBL	ChEMBL275311
E number	{{#property:P628}}
CompTox Dashboard (EPA)	{{#property:P3117}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₄H₂₈O₂
Molar mass	348.486 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C/C(=C\C1=CC=C(C=C1)C(=O)O)/C2=CC3=C(C=C2)C(CCC3(C)C)(C)C
InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ Key:FOIVPCKZDPCJJY-JQIJEIRASA-N

Arotinoid acid

References

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