Arfaptin
Jump to navigation
Jump to search
| Arfaptin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure analysis of rac1-gdp complexed with arfaptin (p21) | |||||||||
| Identifiers | |||||||||
| Symbol | Arfaptin | ||||||||
| Pfam | PF06456 | ||||||||
| Pfam clan | CL0145 | ||||||||
| InterPro | IPR010504 | ||||||||
| SCOP2 | 1i4l / SCOPe / SUPFAM | ||||||||
| CDD | cd00011 | ||||||||
| |||||||||
In molecular biology, the arfaptin domain is a protein domain which interacts with ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. The structure of arfaptin shows that upon binding to a small GTPase, arfaptin forms an elongated, crescent-shaped dimer of three-helix coiled-coils.[1] The N-terminal region of ICA69 is similar to arfaptin.[2]