Amonafide
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| Trade names | Xanafide, Quinamed |
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| E number | {{#property:P628}} |
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| Formula | C16H17N3O2 |
| Molar mass | 283.331 g·mol−1 |
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Amonafide (originally AS1413) (INN, trade names Quinamed and Xanafide) was a drug that was being studied in the treatment of cancer. It belongs to a novel family of chemotherapeutic drugs called Naphthalimides and is a potential topoisomerase inhibitor and DNA intercalator.[1][2]
It was being developed as an anti-cancer therapy by Antisoma.[3]
As of 2008[update], it is in Phase III clinical trials. e.g. In March 2010 it is Phase III trial against secondary acute myeloid leukaemia (AML).[4] In June 2010, it gained an FDA Fast Track Status for the treatment of Secondary Acute Myeloid Leukaemia.[citation needed]
See also
[edit | edit source]References
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- ^ Clinical trial number NCT00715637 for "Phase III Randomized Study of Amonafide (AS1413) and Cytarabine Versus Daunorubicin and Cytarabine in Patients With Secondary Acute Myeloid Leukemia (AML)- the ACCEDE Study" at ClinicalTrials.gov
External links
[edit | edit source]- Amonafide entry in the public domain NCI Dictionary of Cancer Terms
- Clinical trials of amonafide at ClinicalTrials.gov
Public Domain This article incorporates public domain material from Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
