Alsever's solution
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Alsever's solution is a saline liquid used to prevent coagulation of blood.[1][2] It is composed of 2.05% dextrose, 0.8% sodium citrate, 0.055% citric acid, and 0.42% sodium chloride. For usage, an equal volume of blood is gently, but thoroughly, mixed with the solution. This solution is used to study in vitro anti-inflammatory activity of crude drugs by the human red blood cell stabilization method.[3] It is also used to preserve blood cells from other sources.[4][5]
The test was invented in 1941 by the American Hematologist, John Bellows Alsever (1908–1978).[6]
References
[edit | edit source]- ^ Alsever, J. B., & Ainslie, R. B. (1941). A new method for the preparation of dilute blood plasma and the operation of a complete transfusion service. NY State J. Med, 41, 126-131.
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- ^ Gandhisan R, Thamaraichelvan A, Baburaj. Antiinflammatory action of Lannea coromandelica HRBC membrane stabilization. Fitotherapia 1991; 62: 82-83.
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