Adiponectin receptor 2
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene.[1] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2.[2]
Structure
[edit | edit source]Similar to G protein-coupled receptors (GPCRs), AdipoR2 also possesses 7 transmembrane domains. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.[1]
Function
[edit | edit source]The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.[1] In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers.[3]
Ligands
[edit | edit source]Agonists
[edit | edit source]Peptide
[edit | edit source]Non-peptide
[edit | edit source]Antagonists
[edit | edit source]Peptide
[edit | edit source]See also
[edit | edit source]References
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- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016
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- ^ a b c d e Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
External links
[edit | edit source]- Human ADIPOR2 genome location and ADIPOR2 gene details page in the UCSC Genome Browser.
