Adapter molecule crk
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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.[1]
The CRK protein participates in the Reelin signaling cascade downstream of DAB1.[2][3]
Function
[edit | edit source]Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.[4]
Crk together with CrkL participates in the Reelin signaling cascade downstream of DAB1.[2][3]
v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral "gag" protein with the SH2 and SH3 domains of cellular Crk.[5] The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase domains, but capable of stimulating phosphorylation of tyrosines in cells.[6]
Crk should not be confused with Src, which also has cellular (c-Src) and viral (v-Src) forms and is involved in some of the same signaling pathways but is a protein tyrosine-kinase.
Interactions
[edit | edit source]CRK (gene) has been shown to interact with:
- BCAR1,[7][8][9][10][11][12][13][14][15][excessive citations]
- Cbl gene,[16][17]
- Dock180,[18][9][10][19][20]
- EPS15,[21]
- Epidermal growth factor receptor,[22][23]
- Grb2,[24][18][25]
- IRS4,[26][27]
- MAP4K1,[28][29][30]
- MAPK8,[31]
- NEDD9,[32][33]
- PDGFRA,[34][35]
- PDGFRB,[34]
- PTK2,[9][12]
- Paxillin[12][36]
- RAPGEF1,[37]
- RICS,[38][39]
- SH3KBP1,[40] and
- SOS1.[25]
See also
[edit | edit source]- CrkL, "Crk-like" protein
References
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Further reading
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External links
[edit | edit source]- Crk Info with links in the Cell Migration Gateway
- Proto-Oncogene+Proteins+c-crk at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Oncogene+Protein+v-crk at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CRK genome location and CRK gene details page in the UCSC Genome Browser.