Acylphosphatase
| acylphosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||||
| EC no. | 3.6.1.7 | ||||||||
| CAS no. | 9012-34-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| Acylphosphatase | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Structure of acylphosphatase.[2] | |||||||||||
| Identifiers | |||||||||||
| Symbol | Acylphosphatase | ||||||||||
| Pfam | PF00708 | ||||||||||
| InterPro | IPR001792 | ||||||||||
| PROSITE | PDOC00136 | ||||||||||
| SCOP2 | 1aps / SCOPe / SUPFAM | ||||||||||
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In enzymology, an acylphosphatase (EC 3.6.1.7) is an enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates, with acylphosphate and H2O as the two substrates of this enzyme, and carboxylate and phosphate as its two products:[3]
Function
[edit | edit source]This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is acylphosphate phosphohydrolase. Other names in common use include acetylphosphatase, 1,3-diphosphoglycerate phosphatase, acetic phosphatase, Ho 1-3, and GP 1-3.
This enzyme participates in 3 metabolic pathways:
Structural studies
[edit | edit source]Structures of this enzyme have been solved by both NMR and X-ray crystallography. See the links to PDB structures in the info boxes on the right for a current list of structures available in the PDB. The protein contains a beta sheet stacked on two alpha helices described by CATH as an Alpha-Beta Plait fold. The active site sits between sheet and helices and contains an arginine and an asparagine.[4] Most structures are monomeric [5]
Isozymes
[edit | edit source]Humans express the following two acylphosphatase isozymes:
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References
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