ATP6AP1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). The human gene ATP6AP1 encodes the S1 subunit of the enzyme V-type proton ATPase.[1][2][3]
This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is composed of a cytosolic, V1, (site of the ATP catalytic site) and a transmembrane, V0, domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules.[3]
References
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External links
[edit | edit source]- Human ATP6AP1 genome location and ATP6AP1 gene details page in the UCSC Genome Browser.
Further reading
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