ARL1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). ADP-ribosylation factor-like protein 1 is a protein that in humans is encoded by the ARL1 gene.[1]
Function
[edit | edit source]The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.[1]
Interactions
[edit | edit source]ARL1 has been shown to interact with GOLGA4[2][3] and GOLGA1.[2]
References
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External links
[edit | edit source]- Human ARL1 genome location and ARL1 gene details page in the UCSC Genome Browser.
Further reading
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